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Sildenafil citrate, commonly known by the brand name, is a prescription-only medicine used to treat erectile dysfunction (ED) in adult men. It works by improving blood flow to the penis, helping to achieve and maintain an erection during sexual activity.

Dosage and Administration

Sildenafil is available in 25mg, 50mg, and 100mg strengths.

  • The usual starting dose is 50mg, taken approximately one hour before sexual activity.
  • Dosage can be adjusted depending on individual response and tolerability.
  • Take only one tablet in 24 hours, with or without food.
  • Avoid grapefruit juice, as it can increase the risk of side effects.
  • A high-fat meal may delay onset of action.

Effectiveness

Sildenafil has been shown to be effective in up to 80% of men with ED, with effects typically noticeable within 30 to 60 minutes, and lasting for up to 4–5 hours.

Side Effects

Common side effects include:

  • Headache
  • Flushing
  • Nasal congestion
  • Indigestion

Less common but serious effects include visual disturbances, hearing changes, or prolonged erections. Seek medical attention if severe or persistent side effects occur.

Contraindications

Sildenafil should not be used by those:

  • Taking nitrates for chest pain
  • With severe heart or liver conditions
  • Under 18 years of age
  • With certain medication interactions (e.g. alpha-blockers, antifungals, antibiotics)

Interactions

Inform your doctor of all medications and supplements before use. Interactions may occur with:

  • Nitrates
  • Alpha-blockers
  • Some antibiotics and antifungal medicines

Alcohol and Heart Conditions

Avoid excessive alcohol while taking sildenafil, as it can lower blood pressure and increase side effect risk. Use with caution if you have any heart-related conditions.

Availability and Cost

Sildenafil is available by prescription only in the UK.

  • Generic versions are more affordable than branded Viagra.
  • Supplied by licensed UK pharmacies such as Online Chemist.
  • Avoid counterfeit products from unregulated websites.

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Side Effects Tablets

Warning

Do not take Sildenafil if:

  • These disorders are caused by insufficient blood flow to the penis. Do not use in men with diabetes, high blood pressure, heart failure, liver or kidney disease, or who have a history of stroke or high blood pressure.
  • Men with liver or kidney disease have increased levels of alcohol and other medications that can cause liver damage. The combination of these substances can increase the likelihood of jaundice, which may occur as the body adjusts to alcohol.
  • Men with a history of blood clots have a higher risk of developing a condition called retinitis pigmentosa. To avoid this, inform your doctor when taking Sildenafil.

Sildenafil is not recommended for use in women.

Last updated 14 September 2023

On 14 March 2023, the UK Medicines regulator approved an application to reclassify the erectile dysfunction medication Cialis. When marketed asCialis Together(tadalafil 10mg), it will be a ‘P’ (pharmacy) medication, and so available ‘over the counter’ in pharmacies – see. This follows the 2018, ‘P’ classification of (sildenafil 50mg) which has been available OTC, without a prescription, since then.

This decision is good news for men’s health …. Erectile dysfunction can be a debilitating condition, so it’s important men feel they have fast access to quality and legitimate care

Dr Laura Squire, MHRA’s Chief Officer for Healthcare, Quality and Access

Unfortunately, there is a strong black market in the UK for ED medicines, which are often unlicensed or counterfeit. UK Border Force and the MHRA seize millions of pounds of these fake products from criminals annually. This new classification of tadalafil 10mg will enable men who suffer from ED to obtain it safely from a local pharmacy.

Sanofi, the drug manufacturer, is expected to launch Cialis Together later in 2023. Cialis Together will be available to purchase in pharmacies without a prescription by men over 18 with erectile dysfunction. Cialis Together tablets will contain 10mg tadalafil and the maximum pack size will be 8 tablets. Other doses and pack sizes of Cialis and tadalafil will still be available on prescription through doctors and specially trained pharmacists. Before purchase in a pharmacy there must be an assessment with a pharmacist, who will check that Cialis Together is appropriate and safe, or whether consultation with a GP is necessary.

What does this mean for patients?

Men suffering with ED will have another treatment option with the convenience of purchasing it in their local pharmacy, including pharmacies found inside supermarkets (eg. Tesco, Asda, Sainsbury’s). The pharmacist will ask some health questions, may check blood pressure, and will advise on treatment with Cialis Together or Viagra Connect, or the need to consult a GP. Pharmacies usually have a private room for such discussions.

Cialis Together is a 10mg tadalafil product for use at least 30 minutes prior to anticipated sexual activity. Its effects can last. It is not recommended for daily use. The maximum recommended dose of Cialis Together will be one tablet in 24 hours. Prescription Cialis and tadalafil will still be available at different doses.

Dr Fox welcomes the wider access to ED medication for men that Cialis Together classified as a ‘P’ OTC medication will provide. We at Dr Fox are aware of the difficulties men have in discussing ED with their GPs and in accessing ED medication. We know that Cialis is effective and safe for most men and this change provides another option for obtaining ED treatment. Pharmacists are health professionals who are able to give ED advice but they will also know when to refer men who would benefit from a doctor’s assessment. ‘P’ medicines can also be supplied on prescription, and we will offer Cialis Together, when available, alongside our other competitively priced ED products.

Dr Claire Pugh, Dr Fox Medical Director

Categories of medicine

In the UK have 3 categories:

  • POM – Prescription only medicine:supplied by a healthcare professional following a consultation, usually on prescription.
  • P – Pharmacy medicine:supplied by a pharmacist ‘over the counter’, sometimes referred to as ‘P’ medicine or ‘PMED’.
  • GSL – General sales list medicine:available from many retail outlets ‘off the shelf’.
At what age can women be who can begovine h2 xantiban baclofen newzeland

How to ensure Cialis is right for you

Women should not use Cialis because the cause of benign prostatic hyperplasia (BPH) is not yet well understood, but it can be caused by taking other factors, such as diabetes, that are there for some part of the time.

The first clinical study in the field of erectile dysfunction (ED) and pulmonary arterial hypertension is an observational study of 940 men with pulmonary arterial hypertension who were treated for 2 years with the erectile dysfunction drug sildenafil (Viagra).

This trial was designed to test the hypothesis that men with ED would develop pulmonary hypertension. The study followed a course of the same dose of sildenafil (4 mg) administered for 4 weeks. In this study, the men with ED were compared with their counterparts without ED.

A total of 1,000 men were recruited and randomly assigned to take sildenafil (4 mg) or placebo. A total of 1,600 men with ED were treated with sildenafil (4 mg) or placebo. The mean age was 57 years and male subgroup of 80.0% were male. The study group was split into two groups according to their sex and age: sildenafil and placebo groups. The mean age of the placebo and sildenafil groups was 57 and 57, respectively. There were no differences in the mean age of the two groups. There was no difference in the mean age of the sildenafil and placebo groups. There was a significant decrease in systolic blood pressure (SBP) with sildenafil and a significant reduction in diastolic blood pressure (DBP) with placebo in both groups. There were no significant differences in the mean blood pressure differences between groups.

The mean duration of ED was 2 years in the sildenafil group and 4 years in the placebo group. The mean percentage of men who took sildenafil (4 mg) was 83.2%. The mean percentage of men who took placebo (4 mg) was 89.7%. There was no significant difference in the mean percentage of men who took sildenafil (4 mg) in either group.

The results of this study are presented inTable 1.The mean age of the men with ED in the sildenafil and placebo groups was significantly lower (P < 0.001) compared to the mean age in the placebo group. There were no differences in the mean age of the men with ED in either group.

The mean percentage of men who took placebo (4 mg) was 83.1%.

The mean percentage of men who took sildenafil (4 mg) was 89.7%. There were no differences in the percentage of men who took placebo (4 mg) in either group. There were no differences in the percentage of men who took sildenafil (4 mg) in either group.

The mean percentage of men who took sildenafil (4 mg) was 83.1%. The percentage of men who took placebo (4 mg) was 83.1%.

The percentage of men who took placebo (4 mg) was 89.7%.

The cheapest erectile dysfunction (ED) pills are generic Viagra, called.

What is a generic drug?

The term "generic" refers to the active ingredient of a medicine or drug rather than to the advertised brand name under which the medicine is sold. It is a term referring to any drug marketed under its chemical name without advertising.

Pfizer made the originaltablet that is often referred to as the “blue pill”.The patent expired in 2013 which then allowed other pharmaceutical manufactures to make a generic version under the name of the active ingredient called Sildenafil. They are exactly the same medically and perform in the same way with the same side-effects.

As with most branded products, Viagra is sold at a higher price,therefore the generic tablets sold asare much cheaper.

What is the difference between generic and branded drugs?

Medically there is no difference between a generic medicine and the branded medicine, as they both have the same active ingredients to make them perform in the same way. They only differ in the “bulking” agents used to fill the tablet as the amount of active ingredient required, in this case Sildenafil, is very small. This makes the tablets bigger and easier to handle.

The main difference between generic andbranded named prescription medicines is cost with generics being much cheaper

Every pharmacy can choose what price they sell at, as there are no fixed prices. It will depend on what price the pharmacy can buy the drug from the wholesaler and the cost of their own overheads. They can they decide what mark-up they require and some pharmacies choose to sell some products at higher prices.

At Webmed pharmacy we aim to keep our prices as low as possible, without compromising the quality of service, as we arethe only online pharmacy to offercourier guaranteed next working day as standard

We offer a very fast, confidential and discreet service that isby the General Pharmaceutical Council (GPhC) and the Care Quality Commission (CQC).

A large proportion of our sales are made up of returning customers as they have been delighted with our service.

What is the best brand of sildenafil?

When you choose to buy any prescription medication online, you must first of check that the pharmacy is with the General Pharmaceutical Council (GPhC).

All pharmacies using a UK General Medical Council, to prescribe their medicines will also be registered with the UK government Agency the Care Quality Commission (CQC).

Those online pharmacies who are not registered with the CQC either use pharmacist prescribers or foreign doctors.

You will then know and have the confidence that all the brands being offered are genuine and will work in the same way. All the pharmaceutical companies are inspected by the Medicines and Healthcare products Regulatory Agency (MHRA) to ensure they manufacturer the drugs to the same quality standard. This means that the key ingredient that is referred to as the “active” ingredient is exactly the same in all brands.

The other inactive ingredients that make up the bulk of the tablet are called “excipients” and can vary.

For those people who are allergic to or have an intolerance to lactose, then the is ideal for you as it is lactose free. You can check the additional excipients on the patient information leaflet supplied with your tablets.

Although medically all the generic tablets are identical, they may look different as they can vary in colour, shape and size due to the varying excipients.

The patent for, owned by Pfizer, expired in July 2013, which then allowed other pharmaceutical companies to produce generic. There are a number of companies now manufacturing which include Accord, Ajanta, Dr Reddy’s, Mylan, Teva, Torrent and Zentiva. Even Pfizer make a that they sell cheaper than Viagra although generally more expensive than the equivalent generic brands.

Author 19th September 2019

Active ingredient

Sildenafil mg

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